Family Guy marks its landmark 300th episode this Sunday at 9 p.m. on Fox and, somewhere in the cartoon universe, Quahog residents will be gathering in The Drunken Clam to toast the hometown Griffin family.

But, before that happens, there appears to be trouble on the shows Rhode Island horizon heading into Sunday nights Big Celebration: Snarky Baby Stewie is viciously fighting with Brian, the Griffins talking dog, whos vandalized one of Stewies beloved stuffed toys. Bespectacled, paunchy dad Peter, meanwhile, is refusing to wash his hand after using it to greet his favorite breakfast cereal mascot. And who knows what mom Lois and her two teenagers, Meg and Chris, are up to?

Its just another episode in the life of the irreverent Family Guy characters in a series boasting its own colorful past. Created by Seth MacFarlane, Family Guy originally aired on Fox from 1999-2002, before returning to the network for Season 4 in 2005 due to overwhelming demand (and skyrocketing DVD sales). It even inspired a four-season spinoff, The Cleveland Show, starring Peters pal, Cleveland Brown (who returned to Quahog, and to Family Guy, after his starring turn).

So, to honor Family Guys legacy, and its stars, The Post asked Griffin family members Peter, Lois, Meg, Chris, Stewie and Brian to share their biggest memories of the past 16 seasons or to dish on any regrets theyve had over all the years theyve been one of Americas favorite TV families.

Peter: A fond memory for me is gettin hooked on whipped cream canisters way back in Season Four. And Id have to say my biggest regret, easily, is not bringing any to this interview.

Lois: My biggest regret was not doing that daytime talk show the network wanted me to do. With my annoying voice and minimal knowledge of cooking, I easily could have been the next Rachael Ray.

Meg: A lot of prisoners write to me asking for pictures of my feet. I guess thats not a memory or a regret, but I just need someone to know thats what my life has been like because of this show.

Stewie: I regret using a body double for my nude scenes. I see myself in the mirror, and just wow. And I mean that objectively. Like, if I was not me, and I saw me on TV, Id think, I need to see that baby nude. And often. So yeah, expect more full-frontal Stewie going forward. Just, right in front of the camera. No subtlety to it at all.

Brian: Well, as an actor as an artist, really I suppose my only regret is giving every scene my all, and leaving the audience emotionally satisfied after every performance. In a way, I regret not having any regrets to tell you about. Well cocaine. Starting cocaine was a regret. Stopping cocaine, bigger regret.

Chris: Oh, thats easy. My biggest regret was passing on the role of Bart Simpson when they offered it to me in 1989.